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Topic: openclaw

3,425 skills in this topic.

bio-clinical-databases-tumor-mutational-burden Calculate tumor mutational burden from panel or WES data with proper normalization and clinical thresholds. Use when assessing immunotherapy eligibility or characterizing tumor immunogenicity.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-crispr-screens-jacks-analysis JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens) for modeling sgRNA efficacy and gene essentiality. Use when analyzing multiple CRISPR screens simultaneously or when accounting for variable sgRNA efficiency across experiments.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-hi-c-analysis-hic-data-io Load, convert, and manipulate Hi-C contact matrices using cooler format. Read .cool/.mcool files, convert from .hic format, access matrix data, and export to different formats. Use when loading or converting Hi-C contact matrices.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-methylation-methylkit DNA methylation analysis with methylKit in R. Import Bismark coverage files, filter by coverage, normalize samples, and perform statistical comparisons. Use when analyzing single-base methylation patterns, comparing samples, or preparing data for DMR detection.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-engineering-grna-design Design guide RNAs for CRISPR-Cas9/Cas12a experiments using CRISPRscan and local scoring algorithms. Score guides for on-target activity using Rule Set 2 and Azimuth models. Use when designing sgRNAs for gene knockout, activation, or repression experiments.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-intervals-interval-arithmetic
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-engineering-off-target-prediction Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms. Identify potential unintended cleavage sites genome-wide and assess guide specificity. Use when evaluating guide RNA specificity or selecting guides with minimal off-target risk.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-longread-alignment Align long reads using minimap2 for Oxford Nanopore and PacBio data. Supports various presets for different read types and applications. Use when aligning ONT or PacBio reads to a reference genome for variant calling, SV detection, or coverage analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-metagenomics-kraken Taxonomic classification of metagenomic reads using Kraken2. Fast k-mer based classification against RefSeq database. Use when performing initial taxonomic classification of shotgun metagenomic reads before abundance estimation with Bracken.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-metagenomics-abundance Species abundance estimation using Bracken with Kraken2 output. Redistributes reads from higher taxonomic levels to species for more accurate estimates. Use when accurate species-level abundances are needed from Kraken2 classification output.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-genome-assembly-short-read-assembly
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-metabolomics-normalization-qc Quality control and normalization for metabolomics data. Covers QC-based correction, batch effect removal, and data transformation methods. Use when correcting technical variation in metabolomics data before statistical analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-metabolomics-metabolite-annotation Metabolite identification from m/z and retention time. Covers database matching, MS/MS spectral matching, and confidence level assignment. Use when assigning compound identities to detected features in untargeted metabolomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-metabolomics-lipidomics Specialized lipidomics analysis for lipid identification, quantification, and pathway interpretation. Covers LC-MS lipidomics with LipidSearch, MS-DIAL, and LipidMaps annotation. Use when analyzing lipid classes, chain composition, or lipid-specific pathways.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-microbiome-diversity-analysis Alpha and beta diversity analysis for microbiome data. Calculate within-sample richness, evenness, and between-sample dissimilarity with phyloseq and vegan. Use when comparing community composition across samples or testing for group differences in microbiome structure.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-flow-cytometry-fcs-handling Read and manipulate Flow Cytometry Standard (FCS) files. Covers loading data, accessing parameters, and basic data exploration. Use when loading and inspecting flow or mass cytometry data before preprocessing.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-flow-cytometry-doublet-detection Detect and remove doublets from flow and mass cytometry data. Covers FSC/SSC gating and computational doublet detection methods. Use when filtering out cell aggregates before clustering or quantitative analysis.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
alphafold-database Access AlphaFold's 200M+ AI-predicted protein structures. Retrieve structures by UniProt ID, download PDB/mmCIF files, analyze confidence metrics (pLDDT, PAE), for drug discovery and structural biology.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
arboreto Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
armored-cart-design-agent
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
aeon This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bayesian-optimizer
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bgpt-paper-search Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-crispr-screens-crispresso-editing CRISPResso2 for analyzing CRISPR gene editing outcomes. Quantifies indels, HDR efficiency, and generates comprehensive editing reports. Use when analyzing amplicon sequencing data from CRISPR editing experiments to assess editing efficiency.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009