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Topic: nanoclaw

968 skills in this topic.

tooluniverse-variant-analysis Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
travel-health-analyzer 分析旅行健康数据、评估目的地健康风险、提供疫苗接种建议、生成多语言紧急医疗信息卡片。支持WHO/CDC数据集成的专业级旅行健康风险评估。
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
treatment-plans Generate concise (3-4 page), focused medical treatment plans in LaTeX/PDF format for all clinical specialties. Supports general medical treatment, rehabilitation therapy, mental health care, chronic disease management, perioperative care, and pain management. Includes SMART goal frameworks, evidence-based interventions with minimal text citations, regulatory compliance (HIPAA), and professional formatting. Prioritizes brevity and clinical actionability.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
using-superpowers Use when starting any conversation - establishes how to find and use skills, requiring Skill tool invocation before ANY response including clarifying questions
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
usmle Prepare for US medical licensing exams with progress tracking, weak area analysis, question bank management, and residency match planning.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
varcadd-pathogenicity
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
weightloss-analyzer 分析减肥数据、计算代谢率、追踪能量缺口、管理减肥阶段
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
arxiv-search Search arXiv physics, math, and computer science preprints using natural language queries. Powered by Valyu semantic search.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
benchling-integration Benchling R&D platform integration. Access registry (DNA, proteins), inventory, ELN entries, workflows via API, build Benchling Apps, query Data Warehouse, for lab data management automation.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-alignment-io Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-alignment-msa-statistics Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-batch-downloads
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-chipseq-visualization Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions. Use when visualizing ChIP-seq signal and peaks.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-clinical-databases-clinvar-lookup Query ClinVar for variant pathogenicity classifications, review status, and disease associations via REST API or local VCF. Use when determining clinical significance of variants for diagnostic or research purposes.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-clinical-databases-pharmacogenomics Query PharmGKB and CPIC for drug-gene interactions, pharmacogenomic annotations, and dosing guidelines. Use when predicting drug response from genetic variants or implementing clinical pharmacogenomics.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-copy-number-cnv-visualization Visualize copy number profiles, segments, and compare across samples. Create publication-quality plots of CNV data from CNVkit, GATK, or other callers. Use when creating genome-wide CNV plots, sample heatmaps, or chromosome-level visualizations.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-crispr-screens-library-design CRISPR library design for genetic screens. Covers sgRNA selection, library composition, control design, and oligo ordering. Use when designing custom sgRNA libraries for knockout, activation, or interference screens.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-crispr-screens-mageck-analysis MAGeCK (Model-based Analysis of Genome-wide CRISPR-Cas9 Knockout) for pooled CRISPR screen analysis. Covers count normalization, gene ranking, and pathway analysis. Use when identifying essential genes, drug targets, or resistance mechanisms from dropout or enrichment screens.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-data-visualization-circos-plots
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-data-visualization-interactive-visualization
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-de-edger-basics Perform differential expression analysis using edgeR in R/Bioconductor. Use for analyzing RNA-seq count data with the quasi-likelihood F-test framework, creating DGEList objects, normalization, dispersion estimation, and statistical testing. Use when performing DE analysis with edgeR.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-de-results Extract, filter, annotate, and export differential expression results from DESeq2 or edgeR. Use for identifying significant genes, applying multiple testing corrections, adding gene annotations, and preparing results for downstream analysis. Use when filtering and exporting DE analysis results.
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-duplicate-handling
FreedomIntelligence/OpenClaw-Medical-Skills 2,009
bio-entrez-link
FreedomIntelligence/OpenClaw-Medical-Skills 2,009